There is something about the White Sox that brings out the best in the Minnesota Twins.

Kennys Vargas went 4 for 4 with a three-run homer and four RBIs, rookie Byron Buxton had three hits in his first time batting leadoff in the majors, and the Minnesota Twins trounced the Chicago White Sox 13-2 on Monday night.

Joe Mauer homered to start a five-run fourth against starter John Danks (3-8), and Eduardo Nunez punctuated the inning with a two-out, two-run shot. The rally was fueled by a throwing error on shortstop Alexei Ramirez, whose attempt to start a double play sailed into right field.

Brian Dozier added a two-run homer in the eighth for the Twins, who are 8-3 against the White Sox this season while outscoring them 70-28.