Rookie Max Kepler had three two-run homers and six RBIs, leading the Minnesota Twins to a 12-5 win over the Cleveland Indians on Monday night.

Kepler homered off All-Star Danny Salazar in the first and third innings and hit another off Cody Anderson in the sixth. Kepler became the first Twin to homer three times in a game since Justin Morneau in 2007. He also had a single.

Joe Mauer was 4 for 4 and homered in the eighth off Andrew Miller, who was making his first appearance with Cleveland after being acquired Sunday from the Yankees.

Jose Berrios (2-1) retired 15 straight after a three-run first inning. The rookie right-hander, recalled from Triple-A Rochester before the game, allowed four hits in six innings.

Salazar (11-4) lost for the first time since May 22. The right-hander allowed three homers and was charged with six runs in two innings, the shortest outing of his career.