Mookie Betts, the reigning AL MVP, homered on the first two pitches he saw from José Berríos on Wednesday night, collecting four hits and five RBIs in all to help Boston beat the Minnesota Twins 6-2.

Eduardo Rodriguez (17-5) allowed only five singles in seven shutout innings, striking out eight while walking four and hitting a batter. The Red Sox are 12-1 when he starts at Fenway Park.

Ryan Brasier relieved Rodriguez to start the eighth and immediately gave up a single to Cruz and a two-run homer to Eddie Rosario.

Berríos pitched five-plus innings, allowing six runs on eight hits and three walks while striking out six. It was the second-most runs he’s permitted this season.