Lohan's latest brush with the law started shortly before 2:30 a.m. when she drove her black 2010 Porsche Cayenne SUV into an alley between the Maritime Hotel and Dream Hotel on West 16th Street.
Lohan's vehicle clipped a 34-year-old man, police said without elaborating. She got out of the car and entered the Dream Hotel.
"She was involved in a hit and run," a police spokeswoman said.
Lohan, 26, was arrested when she left the hotel a short time later, charged with a misdemeanor and released.
The man, who said his knee was injured, was in stable condition at Bellevue Hospital, police said.
Lohan has been trying to make a comeback after a string of legal and personal troubles, including stints in jail, rehab and court. She was released in March from almost five years of formal probation stemming from a 2007 drunken driving and cocaine possession arrest.