News

Say goodbye to jet lag

Say goodbye to jet lag

Photo: clipart.com

LONDON (Reuters) – Scientists have found a genetic mechanism in mice that hampers their body clock’s ability to adjust to changes in patterns of light and dark, and say their results could someday lead to the development of drugs to combat jet lag.

Researchers from Britain’s Oxford University and from the Swiss drug firm Roche used mice to analyze patterns of genes in an area of the brain called the suprachiasmatic nuclei (SCN) – which in mammals pulls every cell in the body into the same biological rhythm.

They found that one molecule, called SIK1, is key to how the mice responded to changes in light cycles.

When the scientists blocked the activity of SIK1, the mice recovered faster from disturbances in their daily light and dark cycle that had been designed to induce a form of mouse jet lag.

If the corresponding mechanism can be found and similarly blocked in humans, jet lag may become a thing of the past, the researchers said in their study, published online in the journal Cell on Thursday.

“We’re still several years away from a cure for jet lag, but understanding the mechanisms that generate and regulate our circadian clock gives us targets to develop drugs to help bring our bodies in tune with the solar cycle,” said Russell Foster, director of Oxford’s sleep and circadian neuroscience institute.

He said such drugs could also have broader potential value, including for people with mental illnesses where sleep disturbances are common.

Recent Headlines

in Local

The City of Yankton’s Sales Taxes Have Turned Around

Money Coins

After some errors by the state revenue department, the sales taxes for Yankton are looking much better.

in Local

Wanted: Marina Operator

Boater

The current lease for the operation of the marina at the Lewis and Clark State Recreation Area is set to expire at the end of this year, and the South Dakota Department of Game, Fish and Parks is looking for someone interested in taking over.

in Local

Transportation Bill Is Short Term Fix

Road Construction

Before adjourning earlier this month, Congress passed another short term transportation bill. That bill continues the bulk of funding for highway construction projects across the country, but only until next spring.

in Local

District 40 Candidates Debate

WP-Microphone

The two candidates for the District 40 Senate seat in the Nebraska Unicameral debated this week in Hartington.

in Local

Raise For Social Security Recipients

Money Coins

Folks on Social Security will see a one point seven percent increase in their benefits starting on January first.